Publication Updates: Bryan and Anagha's manuscript in accepted for publication in Blood.
BioRxiv preprint can be accessed here:
Chen, B., Deshpande, A., Barbosa, K., Kleppe, M., Li, X., Yeddula, N., Rosa Campos, A., Wechsler-Reya, R.J., Bagchi, A., Meshinchi, S., Eaves, C., Jeremias, I., Haferlach, T., Frank, D.A., Ronai, Z., Chanda, S., Armstrong, S.A., Adams, P.D., Levine, R.L., and Deshpande, A.J*. A JAK/STAT-Mediated Inflammatory Signaling Cascade Drives Oncogenesis in AF10-Rearranged AML BioRxiv (Preprint) 2020 Available from https://doi.org/10.1101/2020.08.31.273631 *corresponding author.
Other manuscripts are posted on BioRxiv while under consideration and can be accessed here:
Sinha S, Barbosa KO, Cheng K, Leiserson MD, Wilson DM, Ryan BM, Ronai ZeA, Lee JS, Deshpande AJ* and Ruppin E*. Integrated computational and experimental identification of p53, KRAS and VHL mutant selection associated with CRISPR-Cas9 editing. BioRxiv 407767 (Preprint). 2019. Available From: BioRxiv doi: https://doi.org/10.1101/407767). *co-corresponding author.
Dominguez A., A, Feng, Y., Campos, A. R., Yin, J., Yang, C., James, B., Murad, R., Kim, H., Deshpande, A. J., Gordon, D. E., Krogan, N., Pippa, R. and Ronai, Z. A. SARS-CoV-2 ORF9c Is a Membrane-Associated Protein that Suppresses Antiviral Responses in Cells. BioRxiv (Preprint) 2020. Available From: BioRxiv doi: https://doi.org/10.1101/2020.08.18.256776)
Khateb, A., Deshpande, A., Feng, Y., Lee, J. S., Lazar, I., Fabre, B., Li, Y., Finlay, D., Fujita, Yu, Z., Tongwu, Y., Jun, Pass, I., Livneh, I., Burian, C., Mason, J. R., Almog, R., Horesh, N., Ofran, Y., Brown, K., Vuori, K., Jackson, M., Ruppin, E., Deshpande, A. J., and Ronai, Z. A. RNF5 Regulation of RBBP4 Defines Acute Myeloid Leukemia Growth and Susceptibility to Histone Deacetylase Inhibitors BioRxiv (Preprint) 2020. Available From: BioRxiv doi: https://doi.org/10.1101/2020.10.25.349241)
Our research group is situated at the Sanford Burnham Prebys Medical Discovery Institute in La Jolla, California. One of the core interests of the lab is to understand regulation of key developmental processes that are important for normal stem cells and are frequently misregulated in human cancer.
We are currently investigating genetic and epigenetic abnormalities in acute myeloid leukemia and lymphoma using mouse models, gene targeting and genome-scale approaches. Our overarching goal is to uncover novel therapeutic nodes of intervention in human hematological malignancies.