OVERVIEW

Our research group is situated at the Sanford Burnham Prebys Medical Discovery Institute in La Jolla, California. One of the core interests of the lab is to understand regulation of key developmental processes that are important for normal stem cells and are frequently misregulated in human cancer.

 

We are currently investigating genetic and epigenetic abnormalities in acute myeloid leukemia and lymphoma using mouse models, gene targeting and genome-scale approaches. Our overarching goal is to uncover novel therapeutic nodes of intervention in human hematological malignancies.